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KMID : 0043320080310020231
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Archives of Pharmacal Research
2008 Volume.31 No. 2 p.231 ~ p.234
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Polymorphism and Pseudopolymorphism of Acyclovir
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Kim Sang-Hee
Sohn Young-Teak
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Abstract
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Four crystal modifications of acyclovir were isolated by recrystallization and characterized by powder X-ray diffractometry, differential scanning calorimetry, and thermogravimetric analysis. It was confirmed that Form 3 is a hydrate and Form 4 is an acetic acid solvate. The dissolution patterns of three crystal forms of acyclovir were studied in water at , 90 rpm for 120 minutes. The amount dissolved at 120 minutes was highest for Form 1, followed by Form 2 and Form 3. After storage of 25 hours at 0% RH (silica gel, ) Form 3 was transformed to Form 2.
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KEYWORD
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Acyclovir, Polymorphism, Pseudopolymorphism, PXRD, DSC, TGA
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